Yescarta: Used to treat certain types of non-Hodgkin lymphoma.

Brief information about it:

Yescarta is a chimeric antigen receptor (CAR) T-cell therapy used to treat certain types of non-Hodgkin lymphoma. It is a type of immunotherapy that involves genetically modifying a patient’s T cells to target and destroy cancer cells.

 Uses:

Non-Hodgkin lymphoma: Yescarta is approved for the treatment of adult patients with large B-cell lymphoma who have relapsed or are refractory to other treatments.

 Mechanism of action:

1. Collecting T cells: T cells are collected from the patient’s blood.
2. Genetic modification: The T cells are genetically modified to express a chimeric antigen receptor (CAR) that recognizes and targets a specific protein on the surface of cancer cells.
3. Expansion and infusion: The modified T cells are grown in a laboratory and then infused back into the patient’s bloodstream.
4. Cancer cell destruction: The CAR T cells identify and attack cancer cells expressing the target protein.

Elimination half life:

The elimination half-life of Yescarta can vary depending on individual factors. It is generally excreted from the body within a few weeks.

Route of Administration:

Yescarta is administered as a single intravenous infusion.

 Side effects:

Yescarta can cause significant side effects, including:

• Cytokine release syndrome (CRS): This is a serious side effect that can cause flu-like symptoms, fever, low blood pressure, and organ damage.
• Neurological toxicity: This can include headaches, confusion, seizures, and other neurological symptoms.
• Infections: Yescarta can weaken the immune system, making you more susceptible to infections.

 Dose:

The recommended dose of Yescarta is a single infusion of 2 x 10^6 CAR-modified T cells per kilogram of body weight.

 Precautions:

·  Consult a doctor: Before receiving Yescarta, consult with a healthcare professional to ensure it is safe for you and to discuss potential risks and benefits.

·  Medical history: Inform your doctor about any personal or family history of conditions such as heart disease, liver disease, or kidney disease.

·  Allergies: Inform your doctor if you have any allergies to medications or other substances.