Aldurazyme: Used for Hunter syndrome.

Brief information about it:

Aldurazyme is an enzyme replacement therapy (ERT) used to treat Hunter syndrome, a rare genetic disorder that causes the buildup of a fatty substance called glycosaminoglycans (GAGs) in the body’s cells.

 Uses:

Hunter syndrome: Aldurazyme is used to replace the missing or deficient enzyme, iduronate-2-sulfatase (IDS), in patients with Hunter syndrome. This helps break down the accumulated GAGs, reducing the symptoms of the disease.

 Mechanism of action:

Aldurazyme is a synthetic enzyme that mimics the natural IDS enzyme. By replacing the missing or deficient enzyme, Aldurazyme helps break down GAGs, reducing the buildup of this fatty substance in the body’s cells. This can alleviate the symptoms of Hunter syndrome, such as coarse facial features, enlarged liver and spleen, intellectual disability, and joint problems.

Elimination half life:

The elimination half-life of Aldurazyme can vary depending on individual factors. It is generally excreted from the body within a few days.

Route of Administration:

Aldurazyme is administered intravenously, meaning it is injected directly into the bloodstream.

 Side effects:

Aldurazyme can cause side effects, including:

• Infections: Aldurazyme can weaken the immune system, making you more susceptible to infections.
• Allergic reactions: Allergic reactions to Aldurazyme are rare but possible.
• Infusion reactions: Some patients may experience infusion reactions, such as fever, chills, or flushing.

 Dose:

The recommended dose of Aldurazyme varies depending on the severity of Hunter syndrome and individual factors. It is typically administered as a regular infusion, either every two weeks or every month.

 Precautions:

·  Consult a doctor: Before receiving Aldurazyme, consult with a healthcare professional to ensure it is safe for you and to discuss potential risks and benefits.

·  Medical history: Inform your doctor about any personal or family history of conditions such as allergies, infections, or immune system disorders.

·  Infections: Avoid exposure to infections before and after receiving Aldurazyme.